2018 Distinguished Achievement Award Winner

Kricket and Jon Seidman

Seidmans

Dr. Kricket Seidman is the T.W. Smith Professor of Medicine & Genetics in the Department of Genetics at Harvard Medical School, is a Howard Hughes Investigator, and is a cardiologist at Brigham and Women's Hospital, where she is also the Director of the Cardiovascular Genetics Center. She has received the American Heart Association Basic Science Prize, the American Society for Clinical Investigation Award, the Glorney-Raisbeck Prize, and the Schottenstein Prize.

Dr. Jon Seidman is the Bugher Foundation Professor of Cardiovascular Genetics, and a former Howard Hughes Investigator. Together they co-direct a lab in cardiovascular genetics that focuses on understanding the causes of hereditary heart disease and have been jointly recognized as recipients of the Pasarow Foundation Award in Cardiovascular Research, the Bristol-Myers Squibb Award for Distinguished Achievement in Cardiovascular Research, and the Institut de France Fondation Lefoulon-Delalande Grand Prix for Science Award.

The Seidmans numerous discoveries have elucidated the role of sarcomeric and other proteins in hypertrophic cardiomyopathy but have also contributed substantially to understanding the role of several genes (such as lamin A/C, eyes-absent-4, phospholamban, myosin heavy chain, troponin T, and titin) in dilated cardiomyopathy. Their recent work in cardiac transcription factor mutations in congenital heart defects has also been groundbreaking. These efforts have enabled improvements in precision diagnostics and therapeutic interventions for these conditions.

By developing and applying advanced sequencing strategies and correlating cardiomyopathy mutations with functional myocyte biology, the Cardiovascular Genetics Center labs have uncovered new and important insights into pathogenic pathways. Using these insights, they (and others) can now target linchpin molecules to develop novel therapeutic strategies to arrest the progression of cardiomyopathies. This is taking us beyond gross and microscopic pathology into the very "heart" of the pathologies of myocardial disease.