As more data emerges from the COVID-19 pandemic, it has become more clear that there is an important cardiovascular component to this disease. Despite a number of clinical papers showing elevated cardiac enzymes, we have almost no pathologic information from hearts. This is an opportunity for all of us to contribute toward the understanding of this disease. If you are perfoming cases and would like to coordinate with other cardiovascular pathologists to help with the diagnosis or to compare across cases, this site can serve as a way to organize these interactions. If you have important data and are looking to get it published quickly to help with our understanding of the pathogenesis, we are prepared to help with that as well.
Cardiovascular related COVID-19 papers
COVID-19 Publications in Cardiovascular Pathology
Questions of interest to the cardiovascular community
Researchers in need of COVID-19 heart tissue samples
A team of researchers at the Gladstone Institutes in San Francisco is interested in obtaining de-identified heart tissue specimens from COVID-19 autopsies for histological analysis. We are particularly interested in immunolocalization of viral proteins and detection of viral RNA (using RNA probes) in myocardial cells. The increased incidence of mortality in patients exhibiting severe cardiac injury is motivating our desire to define the specific mechanisms of viral pathogenesis contributing to acute myocardial injury, myocarditis and potential longer term heart failure in COVID-19 patients. We are currently examining the infection and pathophysiology of SARS-CoV-2 in cardiac cells and tissues derived from human induced pluripotent stem cells. We would like to obtain tissue samples associated with severe cardiac complications for comparative purposes with our in vitro experimental studies, but would also benefit from tissue samples from less severe or non-cardiac cases as controls. Ideally, the levels of cardiac biomarkers (e.g. cardiac troponin (T or I), myoglobin or BNP) in the blood could be provided along with the tissue specimens to correlate the clinical severity with the tissue pathology.