An otherwise healthy 45-year-old male underwent left ventricular assist device placement four days after a large myocardial infarction.
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Extramedullary hematopoiesis in a background of a large myocardial infarction.
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The presence of large atypical cells with frequent mitoses within vascular spaces was highly unexpected. The differential diagnosis included intravascular lymphoma. However, the positive E-cadherin and myeloperoxidase with negative B and T cell markers demonstrated that this was extramedullary hematopoiesis (EMH). EMH can occur throughtout the body and has been demonstrated previously in the heart. REFERENCE: Hill and Swanson "Myocardial extramedullary hematopoiesis: a clinicopathologic study ." Mod Pathol 2000.
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