From the Editor:

Max Buja, Editor


September/October 2012 Issue (Volume 21, Number 5)

Dear Colleagues,

The September-October 2012 issue of Cardiovascular Pathology provides an interesting grouping of reviews and original articles on human cardiovascular disease and experimental studies. Here is the Table of Contents followed by a summary of some key content and messages of the papers:


  • Pathophysiology of Heart Failure (Review)

  • Phosphate Imbalance and Cardiovascular Disease (Review)

  • Experimental Studies:
  • Valvular Interstitial Cell Repair
  • Diabetic Cardiomyopathy
  • Tenacin-C and Atherogenesis
  • Aortic Mechanical Properties

  • Studies of Human Disease:
  • Heterotaxy Syndrome
  • Myocardial C-Reactive Protein and Coronary Heart Disease
  • Cardiac Tumors - Single Center Experience

  • Cornotes

    1) Kemp and Conte review common and uncommon causes of heart failure as well as compensatory mechanisms and therapeutic options for this common final pathway for cardiovascular diseases.

    2) Gonzales-Parra and colleagues review the pathophysiology of phosphate, including effects of extracellular phosphate on vascular calcification and adverse consequences of adaptive mechanisms activated to limit phosphate overload, and discuss the relationship with cardiovascular outcomes.

    3) Han and Gotlieb present evidence that fibroblast growth factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 pathway.

    4) Rouleau and colleagues report that regional variations in canine aortic tissue mechanical properties change with formalin fixation. Formalin fixation preserved regional variation in stiffness and thickness along the aorta, but not local stiffness or anisotropic properties of the tissue.

    5) Wang and colleagues provide experimental evidence that deletion of tenascin-C gene exacerbates atherosclerosis and induces intraplaque hemorrhage in Apo E deficient mice. These data support a protective role for TNC in atherosclerosis and suggest that TNC signaling may have the potential to reduce atherosclerosis, in part by modulating VCAM-1expression.

    6) Gui and colleagues report an association between impairment of multiple parameters of the neuregulin-1/ErbB signaling pathway in relation to severe left ventricular fibrosis and functional impairment in a model of diabetic cardiomyopathy.

    7) In an autopsy-based study of 41 cases, Ware and colleagues have characterized atrial morphology and sinus node morphology in heterotaxy syndrome. Heterotaxy syndrome affects the sidedness of heart, lungs, and abdominal viscera and is associated with complex congenital heart disease.

    8) Joshi and colleagues present results implicating increased prevalence of C-reactive protein in relationship to direct effects on microvascular density and endothelial cell survival in humans with coronary heart disease.

    9) Strecker and colleagues present an analysis of imaging characteristics, surgical treatment and histopathological spectrum of primary and metastatic cardiac tumors based on a 10-year-experience at a German heart center.


    I hope you find interesting information and insights in these papers. I thank the authors for submitting their work to Cardiovascular Pathology and the reviewers for constructive criticism aimed at achieving an optimal final publication.



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    L. Maximilian Buja, M.D.



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